Molecular Formula | C26H27ClN2O3S2
|
Molar Mass | 515.09 |
Density | 1.327±0.06 g/cm3(Predicted) |
Melting Point | 65-70°C |
Boling Point | 712.3±60.0 °C(Predicted) |
Solubility | Soluble in DMSO (up to 50 mg/ml). |
Appearance | Off-white solid. |
Color | Yellow |
pKa | 4.27±0.10(Predicted) |
Storage Condition | Store at -20°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
In vitro study | L-660,711(MK-571) inhibited the binding of [3H]LTD4 in guinea pig lung with a Ki value of 0.22±0.15 nM (n = 35), and inhibited the binding of [3H]LTD4 in human lung, the Ki value was 2.1±1.8 nM (n = 29). L660,711 had low or no activity against [3H]LTC4, and the IC50 in guinea pig lung was 23±11 μm (n = 16), the IC50 in human lung was 32 μm (n = 1). |
In vivo study | MK-571 was well tolerated by healthy young adults. After oral administration, MK-571 is rapidly absorbed. The plasma concentration reached a peak after 1.1-1.5 hours after administration. |